ZITHA SPECIALTYSPECIALTY FIBER CABLES Technical Inquiry

Introduction to Tail Fiber Flanges

Tail fiber flanges are structural domains of bacteriophage tail fibers that facilitate host recognition, attachment, and modular assembly of the fiber complex.Overview of Tail Fibers

Tail fibers are a major class of receptor-binding proteins (RBPs) in bacteriophages, responsible for recognizing and binding to specific bacterial surface receptors such as outer membrane proteins, exopolysaccharides, and flagella . They are typically elongated, flexible, and trimeric, forming long homo-trimeric complexes that attach to the phage tail, often at the baseplate, neck, or other fiber-like adaptors . Tail fibers differ from tail spikes primarily in their mode of action, with spikes often exhibiting depolymerase activity .

Structure and Function of Flanges

Flanges are modular domains within tail fibers that contribute to the stability, flexibility, and host-specific binding of the fiber. They act as structural connectors, linking the fiber to the baseplate or other tail components while maintaining the correct orientation for receptor engagement . Flanges often exhibit pseudo-symmetry, allowing the fiber to assemble into trimeric or higher-order structures, which is critical for the mechanical function of the tail during host attachment and genome delivery .

Classification and Modularity

Recent studies using RBPseg, a computational pipeline combining ESMFold and AlphaFold2-multimer (AF2M), have identified 16 distinct tail fiber classes and 89 domains, highlighting the modular nature of these proteins . Flanges are part of this modular architecture, often conserved across different phages, and can undergo domain swapping, convergence, or divergence, reflecting evolutionary adaptation to diverse bacterial hosts . This modularity allows phages to exchange tail fiber components via horizontal gene transfer, enhancing host range flexibility .

Advances in Structural Modeling

Experimental determination of full-length tail fiber structures is challenging due to their length and flexibility. Computational approaches like RBPseg segment the fiber sequence into manageable fractions using a sigmoid distance pair (sDp) function, predict each segment with AF2M, and assemble them into a complete model . This approach improves model confidence, reduces computational load, and provides insights into the structural organization of flanges and their role in fiber assembly and host interaction .

Functional Implications

Understanding tail fiber flanges is crucial for phage therapy and synthetic biology, as these domains determine host specificity and binding efficiency. By mapping flange structures and their interactions, researchers can engineer phages with tailored host ranges or enhanced stability, expanding their therapeutic potential . In summary, tail fiber flanges are essential structural modules that stabilize the fiber, mediate host attachment, and contribute to the modular evolution of bacteriophage tail fibers, with recent computational tools enabling detailed structural and functional characterization .

Introduction to Tail Fiber Flanges

Tail Fiber: Types, Functions, and Common Interfaces

A tail fiber, also known as a fiber optic patch cord, consists of a connector on one end and a cut end of the fiber optic

RBPseg: Toward a complete phage tail fiber structure atlas

Here, we introduce RBPseg, a method that combines monomeric ESMFold predictions with a

Fiberglass Flanges

Designed for corrosive and demanding environments, fiberglass flanges offer a superior alternative to

Chapter 20965

Here, we will discuss the function and dynamics of the tail of the Caudovirales. We will examine the similarities and differences of all

RBPseg: Toward a complete phage tail fiber structure atlas

Here, we introduce RBPseg, a method that combines monomeric ESMFold predictions with a structural- based domain

Introduction to Flanges

Flanges are used when the piping joint needs dismantling. These are used mainly at

13 Different Types of Flanges and Their Applications

In this article, you will learn the different types of flanges and how they work. Their

Fiber tail fiber characteristics

The ST-type pigtail is usually used for wiring equipment, such as fiber distribution frames,

Tail Fiber Fibbets

With a wide range of color options, this is one of the most comprehensive fibbet ranges on the market. And

Tail Fiber | Microbiology | Fiveable

A tail fiber recognizes the correct bacterial target and attaches the phage to the cell surface. That attachment can trigger later steps

Introduction to Aerospace Flight Vehicles

10 Aerospace Structures Introduction Now that the general anatomy of flight vehicles has been established, it is appropriate to

Tail Fiber: Types, Functions, and Common Interfaces

1. Classification of Tail Fibers Similar to fiber optic jumpers, tail fibers are classified into single-mode and multimode

An Introduction to Fiber Optic Pigtails

Learn more about fiber optic pigtails and how they can help you build a reliable and secure

Towards a complete phage tail fiber structure atlas | bioRxiv

Bacteriophages use receptor-binding proteins (RBPs) to adhere to bacterial hosts. Understanding the structure of

Ares_viral_fibers_AAM

The longitudinal breaking force of an individual long tail fiber (~150 pN) is about twice the force induced by DNA translocation. Thus,

Introduction to Flanges

Introduction to Flanges Flanges are used when the piping joint needs dismantling. These are used mainly at

The function of tail fibers in triggering baseplate expansion of

The correlation of an unstable baseplate and increased ease of contraction with the reduced requirement for tail fiber

Polyvalent phage GSP004 recognizes O-antigen polysaccharide

Polyvalent phage GSP004 recognizes O-antigen polysaccharide receptors in Salmonella and Escherichia coli through

REF Flexi-Flange Fiber

7 Post-Hole Preparation 9-10 Tap / Post Insertion 11-12 Cementation/ Core Formation the introduction of the revolutionary split shank

The Complete Guide to Pigtail Fibers: Simplifying Optical Connectivity

Introduction In the world of fiber optics, where speed and precision reign supreme, pigtail fibers are the unsung

Tail Piece Flange | Tail Piece, Close Flange, Plastic Closed Flange

We are leading Manufacturer and supplier of PVC Tail Piece Flange, Tail Piece Flange, PP Closed Flange, Plastic

(PDF) Introducing Public Administration

Complete with a companion website containing instructor slides for each chapter, a chapter-by-chapter instructor''s manual and

Complete Guide to Piping Flanges: Types, Applications

Comprehensive guide to piping flanges covering all 6 major types: slip-on, weld neck, socket

Fiber tail fiber characteristics

Pigtail, also known as pigtail, has only one end with a connector, and the other end is a

2 Tail fiber function and structure

Hyman, P, & Harrah, T. "Tail fiber function and structure." Bacteriophage T4 Tail Fibers as a Basis for Structured Assemblies. Ed.

Bacteriophage T4 long tail fiber domains

Bacteriophage T4 initially recognizes its host cells using its long tail fibers. Long tail fibers consist of a phage-proximal

What is a Fiber Optic Pigtail, and What Is It Used For?

A fiber optic pigtail is a type of fiber optic cable with only one end that has a factory-terminated connector and the

Introduction to the tail threading process, efficiency and audits

Achieving and maintaining tail threading efficiency is exceedingly important for safety and bottom line performance on

pmc.ncbi m.nih.gov

We would like to show you a description here but the site won''t allow us.

Targeting mechanisms of tailed bacteriophages

The tail structures are key determinants of the host specificity and infection process of the respective phages 4, 5, 6.

Introduction to Aerospace Flight Vehicles

10 Aerospace Structures Introduction Now that the general anatomy of flight vehicles has been established, it is appropriate to

Tail Fiber: Types, Functions, and Common Interfaces

1. Classification of Tail Fibers Similar to fiber optic jumpers, tail fibers are classified into single-mode and multimode

An Introduction to Fiber Optic Pigtails

Learn more about fiber optic pigtails and how they can help you build a reliable and secure

Towards a complete phage tail fiber structure atlas | bioRxiv

Bacteriophages use receptor-binding proteins (RBPs) to adhere to bacterial hosts. Understanding the structure of

Ares_viral_fibers_AAM

The longitudinal breaking force of an individual long tail fiber (~150 pN) is about twice the force induced by DNA translocation. Thus,

Introduction to Flanges

Introduction to Flanges Flanges are used when the piping joint needs dismantling. These are used mainly at

Fiber Optic Adapters Function Introduction

The two fiber optic connectors are installed into the tail ends of the two optical fibers; the coupler plays the role of

Comprehensive Guide to Fiber Optic Pigtails:

Introduction The advent of fiber optic technology has been a cornerstone in the evolution of

Microsoft Word

An Introduction to Pipe Flanges This white paper is provided as a general overview in understanding the most commonly used pipe

13 Different Types of Flanges and Their Applications

In this article, you will learn the different types of flanges and how they work. Their advantages and application with

The function of tail fibers in triggering baseplate expansion of

The correlation of an unstable baseplate and increased ease of contraction with the reduced requirement for tail fiber

Polyvalent phage GSP004 recognizes O-antigen polysaccharide

Polyvalent phage GSP004 recognizes O-antigen polysaccharide receptors in Salmonella and Escherichia coli through

REF Flexi-Flange Fiber

7 Post-Hole Preparation 9-10 Tap / Post Insertion 11-12 Cementation/ Core Formation the introduction of the revolutionary split shank

The Complete Guide to Pigtail Fibers: Simplifying Optical Connectivity

Introduction In the world of fiber optics, where speed and precision reign supreme, pigtail fibers are the unsung

Tail Fiber: Types, Functions, and Common Interfaces

A tail fiber, also known as a fiber optic patch cord, consists of a connector on one end and a cut end of the fiber optic

RBPseg: Toward a complete phage tail fiber structure atlas

Here, we introduce RBPseg, a method that combines monomeric ESMFold predictions with a

Fiberglass Flanges

Designed for corrosive and demanding environments, fiberglass flanges offer a superior alternative to

Chapter 20965

Here, we will discuss the function and dynamics of the tail of the Caudovirales. We will examine the similarities and differences of all

RBPseg: Toward a complete phage tail fiber structure atlas

Here, we introduce RBPseg, a method that combines monomeric ESMFold predictions with a structural- based domain

Introduction to Flanges

Flanges are used when the piping joint needs dismantling. These are used mainly at

13 Different Types of Flanges and Their Applications

In this article, you will learn the different types of flanges and how they work. Their

Fiber tail fiber characteristics

The ST-type pigtail is usually used for wiring equipment, such as fiber distribution frames,

Tail Fiber Fibbets

With a wide range of color options, this is one of the most comprehensive fibbet ranges on the market. And

Tail Fiber | Microbiology | Fiveable

A tail fiber recognizes the correct bacterial target and attaches the phage to the cell surface. That attachment can trigger later steps

Tail Fiber: Types, Functions, and Common Interfaces

A tail fiber, also known as a fiber optic patch cord, consists of a connector on one end and a cut end of the fiber optic

RBPseg: Toward a complete phage tail fiber structure atlas

Here, we introduce RBPseg, a method that combines monomeric ESMFold predictions with a

Fiberglass Flanges

Designed for corrosive and demanding environments, fiberglass flanges offer a superior alternative to

Chapter 20965

Here, we will discuss the function and dynamics of the tail of the Caudovirales. We will examine the similarities and differences of all

RBPseg: Toward a complete phage tail fiber structure atlas

Here, we introduce RBPseg, a method that combines monomeric ESMFold predictions with a structural- based domain

Introduction to Flanges

Flanges are used when the piping joint needs dismantling. These are used mainly at

13 Different Types of Flanges and Their Applications

In this article, you will learn the different types of flanges and how they work. Their

Fiber tail fiber characteristics

The ST-type pigtail is usually used for wiring equipment, such as fiber distribution frames,

Tail Fiber Fibbets

With a wide range of color options, this is one of the most comprehensive fibbet ranges on the market. And

Tail Fiber | Microbiology | Fiveable

A tail fiber recognizes the correct bacterial target and attaches the phage to the cell surface. That attachment can trigger later steps

Technical note

This reference is intended for preliminary specialty-cable research. Compatibility, link budgets, fire performance, installation methods, test limits and applicable standards must be verified for the specific project.

Still Have a Technical Question?

Use the inquiry form to describe a specialty cable route, fire requirement or testing question.

Start an Inquiry